![]() ![]() ![]() The mathematical analogy between response of observers to images and the response of tumors to distributions of a chemotherapy drug is exploited to obtain linear discriminant functions from which AUTOC can be calculated. In radiation therapy, AUTOC can be computed for a single patient by using image data along with radiobiological models for tumor response and adverse side effects. The area under a TOC curve (AUTOC) can be used as a figure of merit for therapeutic efficacy, analogous to the area under an ROC curve ( AUROC), which is a figure of merit for diagnostic efficacy. This paper shows how TOC can be applied to chemotherapy with the administered drug dosage as the variable. The therapy operating characteristic (TOC) curve, developed in the context of radiation therapy, is a plot of the probability of tumor control versus the probability of normal-tissue complications as the overall radiation dose level is varied, e.g., by varying the beam current in external-beam radiotherapy or the total injected activity in radionuclide therapy. Optionally all data can be AES algorithm-encrypted.Therapy operating characteristic curves: tools for precision chemotherapyīarrett, Harrison H. All files may be compressed in gzip, either in toto or separated by subfolders as zip files. The original directory structure remains unchanged beneath these folders. The original drives (C, D, etc.) appear as subdirectories LwC, LwD, etc. Additional criteria are the selection by file type, file age, and file name filter. But the user can exclude or include any subdirectories from or in the backup by selection or a filter. All subfolders are included automatically. The selection of the files to be backed up is made on a by-folder basis. You can configure and store as many backup tasks as you wish. Personal Backup saves personal data to any destination folder located on a local fixed or removable drive, Windows network server, or an FTP server. ![]()
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